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Search Results for " alzheimer’s disease "

74

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1460	Dicyclomine hydrochloride	AChR	Neuroscience
	Dicyclomine hydrochloride 是口服活性毒蕈碱胆碱能受体拮抗剂。它是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。它对 M1 受体亚型和 M2 受体亚型，Ki 分别为5.1和54.6nM，在刷状缘膜和基底质膜中均表现出较高的亲和力。
T2171	SEW2871 SEW2871	S1P Receptor; LPL Receptor	GPCR/G Protein
	SEW 2871 是一种可口服的高选择性 S1P1激动剂，EC50为 13.8 nM。它减少血液中的淋巴细胞数量，可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路，并诱导 S1P1 内在化和再循环。
T6870	L-685458 L-685,458	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	L-685458 (L-685,458) 是一种过渡状态模拟 γ-分泌酶抑制剂，抑制淀粉样 β-蛋白前体 γ-分泌酶活性，选择性高于其他检测的天冬氨酸蛋白酶 50-100 倍。它抑制 γ-分泌酶介导的 APP-C99 和 Notch-100 的裂解，可研究阿尔茨海默病和癌症。
T16133	MRK-560	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	MRK-560 是高效的、口服有效的 γ- 分泌酶抑制剂抑制剂，具有大脑屏障渗透性。
T12165	nAChR agonist 1 DUN71755	AChR	Neuroscience
	nAChR agonist 1 (DUN71755) 是一种脑渗透性和口服有效的正变构 α7 烟碱乙酰胆碱受体 (α7 nAChR) 调节剂。它在 Ca2+中，对内源性表达 α7 nAChR 的人 IMR-32 神经母细胞瘤细胞的EC50为 0.32 μM。它可用于阿尔茨海默病的研究。
T9725	GSK-3β inhibitor 10	Others	Others
	GSK-3β inhibitor 10 具有美白、抗氧化和 PPAR 活性。
TQ0003	740 Y-P 740YPDGFR,PDGFR 740Y-P	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	740 Y-P (740YPDGFR) 是一个细胞渗透性PI3K 激活剂。它能结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白。
T3198L	PRE-084 hydrochloride	Sigma receptor	GPCR/G Protein
	PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。
T16079	Mirodenafil 米罗那非,SK3530	PDE	Metabolism
	Mirodenafil 是一种磷酸二酯酶5（PDE-5）抑制剂，可用于勃起功能紊乱的研究。
T15199	Edicotinib JNJ-527,JNJ-40346527	c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Edicotinib (JNJ-527) 是能够透过血脑屏障的、口服具有活性的、选择性的CSF-1R 抑制剂 (IC50:3.2 nM)。它对 KIT (IC50:20 nM) 和 FLT3 (IC50:190 nM) 的抑制作用较小。它抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。它可用于研究阿尔茨海默病和类风湿性关节炎。
TQ0126	Mirodenafil dihydrochloride SK-3530 dihydrochloride,米罗那非二盐酸盐	PDE	Metabolism
	Mirodenafil dihydrochloride 是一种磷酸二酯酶5（PDE-5）抑制剂，可作用于勃起功能紊乱的研究。
T1637	Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺	Mitophagy; Beta Amyloid; Others; Ferroptosis; HIF/HIF Prolyl-Hydroxylase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Metabolism; Neuroscience; Others
	Deferoxamine Mesylate (DFOM) 是一种铁螯合剂和铁死亡抑制剂。Deferoxamine Mesylate 可将游离铁结合成稳定的复合物，减少铁的积累。Deferoxamine Mesylate 可以上调 HIF-1α 水平，诱导细胞凋亡。
TP2045	CH 275
	Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens
T12901	SHIP2-IN-1	Phosphatase	Metabolism
	SHIP2-IN-1 是一种 SHIP2 抑制剂，IC50=2 µM。它能够使 GSK3β 的 Ser9 位点磷酸化，抑制 GSK3β 的活化。它可用于研究阿尔滋海默症。
T9379	L-Threonic acid magnesium salt	Others	Others
	L-Threonic acid magnesium salt 可增加老年大鼠和晚期阿尔茨海默病 (AD) 模型小鼠的突触密度和记忆能力。
T10841	CM-675	HDAC; PDE	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	CM-675 是磷酸二酯酶 5 (PDE5)和I 类组蛋白去乙酰化酶 (HDAC1) 的选择性抑制剂，对 PDE5 和 HDAC1 的IC50 值分别为114 nM 和673 nM。CM-675 可用于阿尔兹海默症的研究。
T10630	BuChE-IN-TM-10 TM-10	AChR	Neuroscience
	BuChE-IN-TM-10 (TM-10) 是一种有效的丁基胆碱酯酶 (BuChE) 抑制剂，其IC50 值为8.9 nM。BuChE inhibitor 1能够抑制和分解自诱导的Aβ聚合, 表现出强大的抗氧化活性和良好的血脑屏障 (BBB) 渗透性。可用于阿尔兹海默症的研究。
T16037	GLN-1062	Others	Others
	GLN-1062 是 galantamine 的前体药物，在阿尔兹海默症中有研究价值。
T28735	SCH-900229 SCH 900229,SCH900229
	SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer’s Disease.
T61423	Transthyretin-IN-1
	Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T11448	GOAT-IN-1	Others	Others
	GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral infa
T30266	AZD8926 AZD 8926,AZD-8926
	AZD8926 is a potent and selective inhibitor of GSK3β(glycogen synthase kinase-3β). AZD8926 is potential for treating Alzheimer’s disease (AD), schizophrenia, and chronic as well as acute neurodegenerative diseases.
T37531	Glycerophosphorylethanolamine (sodium salt)
	Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2It promotes aggregation of amyloid-β (1-40) (Aβ40)in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer’s disease. 1.Klunk, W.E., Xu, C.J., McClure, R.J., et al.Aggregation of β-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brainJ. Neurochem.69(1)266-272(1997) 2.Blusztajn, J.K...
TP1673	β-Amyloid (11-22) β-Amyloid 11-22
	β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerat
T68257	Hydromethylthionine HBr
	Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.
T80878	Vanutide cridificar PF 05236806,ACC-001
	Vanutide cridificar (ACC-001)是一种氨基末端Aβ1-7肽的偶联物，用于阿尔茨海默病(AD)的研究。
T76738	Bapineuzumab
	Bapineuzumab，一种针对β-淀粉样蛋白(APP)的单克隆抗体，适用于阿尔茨海默病(AD)的研究。
TP1866	β-Amyloid (1-11) β-amyloid 1-11
	Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients.
T75780	LPYFD-NH2 TFA
	LPYFD-NH2 TFA, 作为一种五肽, 具有抑制Aβ(1-42)聚集的功能, 适用于阿兹海默症的研究。
TP2171	β-amyloid (12-28) (TFA) (107015-83-8 free base) Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA)	Others	Others
	β-amyloid (12-28) TFA, a peptide fragment of β-amyloid protein (β1-42), is the major component of senile plaque cores. β-amyloid (12-28) has aggregation properties and the potential for Alzheimer’s disease research.
T76827	Solanezumab
	Solanezumab是一种人源化单克隆IgG1抗体，针对amyloid-β(Aβ)肽中间结构域，展现出对阿尔茨海默症研究的潜力。
T80695	β-Amyloid precursor protein (96-110), cyclized (human)
	β-Amyloid precursor protein (96-110), cyclized (human) 为一种淀粉样前体蛋白衍生物，特别适用于阿尔茨海默病相关研究。
T76464	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
	FITC-β-Ala-Amyloid β-Protein (1-42) ammonium 是一种关键于阿尔茨海默病发病机制中的 FITC 标记 Aβ1-42 单体肽。
T35892	Q134R Q134R
	Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...
T76926	Bepranemab
	Bepranemab (UCB 0107)为人源化全长IgG4单克隆抗体，特异性结合中央tau表位（氨基酸235-250）。该化合物适用于阿尔茨海默病(AD)研究。
T77028	Gosuranemab
	Gosuranemab (BMS-986168) 是一种人源化 IgG4抗tau 单克隆抗体。Gosuranemab 与人 N 端 tau 残基 15-22 结合。Gosuranemab 具有用于阿尔茨海默病 (AD) 研究的潜力。
T38005	P11149
	P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer’s disease[1]. P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].P11149 exhibits greater s.c. bioavailability than p.o. [1].Oral P11149 in mice pr...
T79011	TrkB-IN-1	Trk receptor	Tyrosine Kinase/Adaptors
	TrkB-IN-1为一种有效的口服活性TrkB激动剂，展现出优良的药代动力学特性。该化合物能够逆转AD模型小鼠的认知功能缺陷，适用于阿尔茨海默病的研究。
T72471	Antioxidant agent-2
	Antioxidant agent-2 (comp 3c) 为能穿过血脑屏障的抗氧化剂与选择性金属离子螯合剂，表现出优异的神经保护与肝脏保护活性，适用于阿尔兹海默病研究。
T35560	SAR502250
	SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic...
T83204	Acetly-β Amyloid(15-20), Amide
	Acetly-β Amyloid (15-20), Amide 为多肽片段，具有抑制 Aβ (1–40) 肽β-折叠形成并稳定其结构的功能，适用于阿尔茨海默病的相关研究。
T39492	FRM-024
	FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.
T10443	Aβ42-IN-1 free base	Others	Others
	Aβ42-IN-1 free base是一种口服活性的γ-secretase调节剂，具有高暴露度。该化合物能显著降低小鼠脑中Aβ42的水平，IC50为0.091 μM，显示出在阿尔茨海默病研究中的潜力。
T27051	CM-414 CM 414,CM414
	CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer’s Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively). Chronic treatment of Tg2576 mice with CM-414 dimini
T72791	AChE/MAO-B-IN-3
	AChE/MAO-B-IN-3 是AChE 和MAO-B 的抑制剂，对人AChE 和MAO-B 的IC50分别为 0.0257 μM 和 0.0456 μM。AChE/MAO-B-IN-3 可用于阿尔兹海默症的研究。
T60824	Dyrk1A-IN-3
	Dyrk1A-IN-3 (Compound 8b) 是双特异性酪氨酸调节激酶 1A (DYRK1A) 的高选择性抑制剂。Dyrk1A-IN-3与 DYRK1A 结合具有高结合亲和力，IC50值为76 nM。Dyrk1A-IN-3可用于研究神经退行性疾病，例如，阿尔茨海默病、亨廷顿病和帕金森病等。
T76395	(Met(O)35)-Amyloid β-Protein (1-42)
	'(Met(O)35)-Amyloid β-Protein (1-42)，Aβ42的一种氧化形态，位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体，适用于阿尔茨海默病（AD）研究。'
T72808	(R)-TTBK1-IN-1
	TTBK1-IN-1 是一种强效、选择性、脑渗透型 tau 微管蛋白激酶 1 (TTBK1) 抑制剂。(R)-TTBK1-IN-1 是 TTBK1-IN-1 的对映体。TTBK1-IN-1 可用于阿尔茨海默病及相关疾病的研究。
T79501	PD10
	PD10为同时针对AChE与BuChE的抑制剂，在人脑AChE (hAChE IC50: 0.56 μM)、电鳗AChE (eeAChE IC50: 0.59 μM)、马血清BuChE (eqBuChE IC50: 1.06 μM) 均有显著抑制效果，适用于阿尔茨海默病相关研究。
T74578	3'-DMTr-dG(iBu)
	3'-DMTr-dG(iBu)是一种应用于核酸合成的核苷，专用于合成用于研究乙型肝炎病毒(HBV)、丁型肝炎病毒(HDV)感染治疗的抗病毒剂，以及开发针对阿尔茨海默病和其他tau蛋白病治疗的寡核苷酸。

化合物

Dicyclomine hydrochloride

Cat.No: T1460

Target: AChR

Cat.No: T2171

Synonym: SEW2871

Target: S1P Receptor, LPL Receptor

Cat.No: T6870

Synonym: L-685,458

Target: Apoptosis, Gamma-secretase

Cat.No: T16133

Target: Gamma-secretase

nAChR agonist 1

Cat.No: T12165

Synonym: DUN71755

Target: AChR

GSK-3β inhibitor 10

Cat.No: T9725

Target: Others

Cat.No: TQ0003

Synonym: 740YPDGFR,PDGFR 740Y-P

Target: PI3K, Autophagy

PRE-084 hydrochloride

Cat.No: T3198L

Target: Sigma receptor

Cat.No: T16079

Synonym: 米罗那非,SK3530

Target: PDE

Cat.No: T15199

Synonym: JNJ-527,JNJ-40346527

Target: c-Fms, FLT, CSF-1R, c-Kit

Mirodenafil dihydrochloride

Cat.No: TQ0126

Synonym: SK-3530 dihydrochloride,米罗那非二盐酸盐

Target: PDE

Deferoxamine Mesylate

Cat.No: T1637

Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺

Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy

Cat.No: TP2045

Cat.No: T12901

Target: Phosphatase

L-Threonic acid magnesium salt

Cat.No: T9379

Target: Others

Cat.No: T10841

Target: HDAC, PDE

Cat.No: T10630

Synonym: TM-10

Target: AChR

Cat.No: T16037

Target: Others

Cat.No: T28735

Synonym: SCH 900229,SCH900229

Transthyretin-IN-1

Cat.No: T61423

Cat.No: T11448

Target: Others

Cat.No: T30266

Synonym: AZD 8926,AZD-8926

Glycerophosphorylethanolamine (sodium salt)

Cat.No: T37531

β-Amyloid (11-22)

Cat.No: TP1673

Synonym: β-Amyloid 11-22

Hydromethylthionine HBr

Cat.No: T68257

Vanutide cridificar

Cat.No: T80878

Synonym: PF 05236806,ACC-001

Cat.No: T76738

β-Amyloid (1-11)

Cat.No: TP1866

Synonym: β-amyloid 1-11

Cat.No: T75780

β-amyloid (12-28) (TFA) (107015-83-8 free base)

Cat.No: TP2171

Synonym: Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA)

Target: Others

Cat.No: T76827

β-Amyloid precursor protein (96-110), cyclized (human)

Cat.No: T80695

FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)

Cat.No: T76464

Cat.No: T35892

Synonym: Q134R

Cat.No: T76926

Cat.No: T77028

Cat.No: T38005

Cat.No: T79011

Target: Trk receptor

Antioxidant agent-2

Cat.No: T72471

Cat.No: T35560

Acetly-β Amyloid(15-20), Amide

Cat.No: T83204

Cat.No: T39492

Aβ42-IN-1 free base

Cat.No: T10443

Target: Others

Cat.No: T27051

Synonym: CM 414,CM414

AChE/MAO-B-IN-3

Cat.No: T72791

Cat.No: T60824

(Met(O)35)-Amyloid β-Protein (1-42)

Cat.No: T76395

Cat.No: T72808

Cat.No: T79501

3'-DMTr-dG(iBu)

Cat.No: T74578

Cat. No.	Product Name	Target	Signaling Pathways
T3769	Tenuifolin	Others; Beta-Secretase; AChE	Neuroscience; Others
	Tenuifolin 是一种从远志中分离出的三萜，能够抑制β-secretase 以减少 Aβ 蛋白分泌，具有神经保护作用。它可通过降低 AChE 活性来改善衰老小鼠的学习和记忆能力，有潜力用于阿尔茨海默氏病的研究。
T5S1923	Schisandrin C 五味子丙素,Schizandrin-C,Wuweizisu-C	Apoptosis; Others; Virus Protease	Apoptosis; Microbiology/Virology; Others
	Schisandrin C (Wuweizisu-C) 是从五味子中分离得到的一种植物化学木脂素。它具有抗癌、抗炎和抗氧化等多种生物活性，可研究癌症、阿尔茨海默病、肝病。
T2S1200	Sinapine	Antioxidant; P-gp; AChE	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Sinapine 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T3248	alpha-Boswellic acid α-Boswellic acid,α-乳香酸	Others	Others
	alpha-Boswellic acid (α-Boswellic acid) 是一种从乳香中提取得到的五环三萜类天然产物，具有抗惊厥和抗癌作用。在动物体内，它是预防和减少阿尔茨海默病标志物，可用于阿尔茨海默病的研究。
T3392	Sinapine thiocyanate	P-gp; AChE	Membrane transporter/Ion channel; Neuroscience
	Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T3933	Jatrorrhizine Yatrorizine,neprotin,药根碱	MAO; 5-HT Receptor; Antibacterial; AChE	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱，具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
T4912	Jatrorrhizine chloride 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride	Others; 5-HT Receptor; OCT; Antibacterial; AChE	GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
T5297	3-Indolepropionic acid Indolepropionic acid,IPA,indole-3-propionic acid,吲哚-3-丙酸	Antioxidant; Reactive Oxygen Species; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	3-Indolepropionic acid (Indolepropionic acid) 是强效的抗氧化剂，具有研究阿尔兹海默症的潜能。
T38606	Sinapine hydroxide
	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4].
T79973	Dehydrodiscretamine chloride
	Dehydrodiscretamine chloride作为AChE和BChE的双重抑制剂，展现了其抑制效力，其中对AChE的IC50为17.8 μM，对BChE的IC50为118.8 μM。此外，该化合物具备抗氧化活性，并可被应用于阿尔茨海默病相关研究。
T75628	Methyl ganoderate A acetonide
	Methyl ganoderate A acetonide，羊毛甾烷三萜类化合物，是一种可从灵芝子实体中分离得到天然产物。Methyl ganoderate A acetonide 是一种有效的 AChE 抑制剂，IC50值为 18.35 μM。Methyl ganoderate A acetonide 可用于阿尔茨海默病 (AD) 的研究。
T75544	AChE/BChE-IN-11
	AChE/BChE-IN-11 (compound 1) 是一种有效的 AChE 和 BChE 双重抑制剂，AChE 和BChE 的IC50值为分别为 70 和 71 μM。AChE/BChE-IN-11 是一种天然产物，可以从朝鲜蓟叶中分离得到。AChE/BChE-IN-11 可用于阿尔茨海默病 (AD) 研究。

天然产物

Cat.No: T3769

Target: Others, Beta-Secretase, AChE

Cat.No: T5S1923

Synonym: 五味子丙素,Schizandrin-C,Wuweizisu-C

Target: Apoptosis, Others, Virus Protease

Cat.No: T2S1200

Target: Antioxidant, P-gp, AChE

alpha-Boswellic acid

Cat.No: T3248

Synonym: α-Boswellic acid,α-乳香酸

Target: Others

Sinapine thiocyanate

Cat.No: T3392

Target: P-gp, AChE

Cat.No: T3933

Synonym: Yatrorizine,neprotin,药根碱

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Jatrorrhizine chloride

Cat.No: T4912

Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

3-Indolepropionic acid

Cat.No: T5297

Synonym: Indolepropionic acid,IPA,indole-3-propionic acid,吲哚-3-丙酸

Target: Antioxidant, Reactive Oxygen Species, Endogenous Metabolite

Sinapine hydroxide

Cat.No: T38606

Dehydrodiscretamine chloride

Cat.No: T79973

Methyl ganoderate A acetonide

Cat.No: T75628

AChE/BChE-IN-11

Cat.No: T75544

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